6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

Chemical Name:6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
CAS No.:1352130-67-6
Molecular Formula:C₂₇H₂₉ClN₆O₃S
Molecular Weight:553.085
Hs Code.:

Synonyms:6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Property of 6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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Technology Process of 6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

There total 7 articles about 6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1346555-48-3
1-bromo-2-chloro-4-(methylsulfonyl)benzene

: 1286738-88-2
8-ethyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-boronic acid

: 1352130-67-6
6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 211244-81-4
2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352130-67-6
6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

2.2: 1.5 h / 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C

4.1: 3 h / 120 °C

5.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; potassium acetate; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 352328-87-1
6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352130-67-6
6-(2-chloro-4-methanesulfonyl-phenyl)-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

1.2: 1.5 h / 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C

3.1: 3 h / 120 °C

4.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;