(S)-2-AMINO-2-METHYL-4-PENTENOIC ACID

Base Information

• Chemical Name: (S)-2-AMINO-2-METHYL-4-PENTENOIC ACID
• CAS No.: 16820-25-0
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.16
• Mol file: 16820-25-0.mol

Synonyms:3-Butenoicacid, 2-amino-2-methyl-, (S)- (8CI);

Chemical Property of (S)-2-AMINO-2-METHYL-4-PENTENOIC ACID

Chemical Property:

• Vapor Pressure: 0.00946mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 245.3 °C at 760 mmHg
• Flash Point: 102.1 °C
• PSA: 63.32000
• Density: 1.101 g/cm³
• LogP: 1.06480

Purity/Quality:

98%min ^*data from raw suppliers

ALPHA-ALLYL-L-ALA 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-2-METHYL-4-PENTENOIC ACID

There total 14 articles about (S)-2-AMINO-2-METHYL-4-PENTENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-(S)-2-Benzoylamino-2-methyl-4-phenylselanyl-but-3-enoic acid methyl ester (314774-43-1) → (+)-(2S)-α-Methyl-α-vinylglycine (16820-25-0,109958-86-3)

Guidance literature:

(E)-(S)-2-Benzoylamino-2-methyl-4-phenylselanyl-but-3-enoic acid methyl ester; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Heating;

With oxonium; Heating;

DOI:10.1021/ja0055110

Reference yield: 87.0%

(S)-2-Methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-enoic acid → (+)-(2S)-α-Methyl-α-vinylglycine (16820-25-0,109958-86-3)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 0.166667h;

DOI:10.1021/jo00074a016

Reference yield: 81.0%

4-methyl-2-phenyl-4-vinyloxazol-5(4H)-one → (+)-(2S)-α-Methyl-α-vinylglycine (16820-25-0,109958-86-3)

Guidance literature:

With trifluoroacetic acid; In water; at 100 ℃; for 12h;

DOI:10.1002/ejoc.201700353

upstream raw materials:

N-Methoxyacetyl-α-methyl-α-vinylglycine

(S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid

(E)-(S)-2-Benzoylamino-2-methyl-4-phenylselanyl-but-3-enoic acid methyl ester

(4S,5R)-4-Methyl-2-phenyl-5-phenylselanylmethyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Downstream raw materials:

(S)-2-(benzyloxycarbonylamino)-2-methylbut-3-enoic acid