3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

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Chemical Name:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide
CAS No.:1307895-98-2
Molecular Formula:C₂₃H₂₄N₆O₂
Molecular Weight:416.483
Hs Code.:

Synonyms:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

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Chemical Property of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

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Technology Process of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

There total 2 articles about 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₃₄H₄₆N₆O₄Si

: 1307895-98-2
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

Guidance literature:: C₃₄H₄₆N₆O₄Si; With trifluoroacetic acid; In dichloromethane; at 20 - 25 ℃; for 16h;

With hydrogenchloride; In water; at 20 ℃; for 8h;

Reference yield:

: 1307896-81-6
tert-butyl 7-(3-(tert-butyldimethylsilyloxy)propyl)-6-formyl-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

: 15029-37-5
2-cyano-N-cyclopropylacetamide

: 1307895-98-2
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-cyclopropylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 13 h / -20 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 - 25 °C

2.2: 8 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;