(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester
CAS No.:189017-52-5
Molecular Formula:C₂₆H₄₁N₃O₆
Molecular Weight:491.628
Hs Code.:

Synonyms:(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

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Chemical Property of (S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

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Technology Process of (S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

There total 5 articles about (S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40856-59-5,132957-40-5
tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

: 189017-52-5
(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / tetrahydrofuran; ethanol

2: PCC/silica gel / CH₂Cl₂ / 2.5 h

3: acetic acid; methanol / 0.08 h / Ambient temperature

4: NaCNBH₃ / acetic acid; methanol / 3 h / Ambient temperature

5: 83 percent / DIPEA, DMAP / CH₂Cl₂

With dmap; silica gel; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jo962257e

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189017-52-5
(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / Et₃N / dimethylformamide

2: 100 percent / tetrahydrofuran; ethanol

3: PCC/silica gel / CH₂Cl₂ / 2.5 h

4: acetic acid; methanol / 0.08 h / Ambient temperature

5: NaCNBH₃ / acetic acid; methanol / 3 h / Ambient temperature

6: 83 percent / DIPEA, DMAP / CH₂Cl₂

With dmap; silica gel; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo962257e

Reference yield:

: 189017-50-3
((S)-1-Dimethylcarbamoyl-3-hydroxy-propyl)-carbamic acid tert-butyl ester

: 189017-52-5
(S)-2-[Acetyl-((S)-3-tert-butoxycarbonylamino-3-dimethylcarbamoyl-propyl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PCC/silica gel / CH₂Cl₂ / 2.5 h

2: acetic acid; methanol / 0.08 h / Ambient temperature

3: NaCNBH₃ / acetic acid; methanol / 3 h / Ambient temperature

4: 83 percent / DIPEA, DMAP / CH₂Cl₂

With dmap; silica gel; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jo962257e