3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid

Base Information

• Chemical Name: 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid
• CAS No.: 878420-30-5
• Molecular Formula: C₁₈H₁₇N₃O₄S
• Molecular Weight: 371.417
• Mol file: 878420-30-5.mol

Synonyms:3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid

Chemical Property of 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid

There total 2 articles about 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.54%

3-(2-chloroacetamido)-4-methylbenzoic acid + 2-Mercapto-5-methoxybenzimidazole (37052-78-1) → 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid (878420-30-5)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Reflux;

DOI:10.1016/j.ejmech.2013.10.030

Reference yield:

3-amino-p-toluic acid (2458-12-0) → 3-(2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamido)-4-methylbenzoic acid (878420-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / 20 °C

2: potassium carbonate / acetone / 6 h / Reflux

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2013.10.030

upstream raw materials:

2-Mercapto-5-methoxybenzimidazole

3-amino-p-toluic acid