(1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate

Base Information

• Chemical Name: (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate
• CAS No.: 137693-54-0
• Molecular Formula: C₁₅H₂₆O₂
• Molecular Weight: 238.37
• Mol file: 137693-54-0.mol

Synonyms:(1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate

Chemical Property of (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate

There total 4 articles about (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Tiglic acid (80-59-1) + (1S,2R,5S)-(+)-menthol (15356-60-2) → (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate (137693-54-0)

Guidance literature:

With p-nitrobenzoic anhydride; scandium tris(trifluoromethanesulfonate); In nitromethane; for 2h; Ambient temperature;

DOI:10.1021/ja00120a030

Reference yield:

→ l-Menthylangelat (67801-23-4,72447-47-3,93059-70-2,97672-26-9,137693-53-9,137693-54-0)

Guidance literature:

l-Menthyl-3-bromangelat;

Reference yield:

(1S,2R,5S)-(+)-menthol (15356-60-2) + C10H16O3 (137601-33-3) → Angelicasaeure-l-menthylester (137693-53-9) + (1S,3R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl (E)-2-methyl-2-butenoate (137693-54-0) + (2R,5S)-2-isopropyl-5-methyl-cyclohexyl 2,2-dimethylpropanoate (137601-34-4)

Guidance literature:

With dmap; In toluene; at 70 ℃; for 14h; or with angelic anhydride;

DOI:10.1016/S0040-4039(00)93432-4

upstream raw materials:

(1S,2R,5S)-(+)-menthol

C₁₀H₁₆O₃

Tiglic acid

Angelic acid