ETHOXYACETIC ACID HYDRAZIDE

Base Information

• Chemical Name: ETHOXYACETIC ACID HYDRAZIDE
• CAS No.: 39242-95-0
• Molecular Formula: C4H10N2O2
• Molecular Weight: 118.136
• Hs Code.: 2928000090
• Mol file: 39242-95-0.mol

Synonyms:Aceticacid, ethoxy-, hydrazide (9CI);Ethoxyacethydrazide;2-Ethoxyacetohydrazide;

Chemical Property of ETHOXYACETIC ACID HYDRAZIDE

Chemical Property:

• Vapor Pressure: 0.00755mmHg at 25°C
• Refractive Index: 1.446
• Boiling Point: 268.8 °C at 760 mmHg
• PKA: 12.40±0.18(Predicted)
• Flash Point: 116.3 °C
• PSA: 64.35000
• Density: 1.068 g/cm³
• LogP: 0.10400

Purity/Quality:

98%Min ^*data from raw suppliers

2-Ethoxyacetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHOXYACETIC ACID HYDRAZIDE

There total 1 articles about ETHOXYACETIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-ethoxyethanoate (817-95-8) → 2-ethoxyacetylhydrazine (39242-95-0)

Guidance literature:

With hydrazine hydrate;

Reference yield: 76.0%

2-ethoxyacetylhydrazine (39242-95-0) + methyl (E)-3-(3-chloro-5-fluoro-1H-indol-1-yl)-N-(6-methoxypyridin-3-yl)azetidine-1-carbimidothioate → 3-chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)azeti din-3-yl)-5-fluoro-1H-indole

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 70 ℃; for 3h;

Reference yield: 62.2%

2-ethoxyacetylhydrazine (39242-95-0) + methyl (E)-3-(5-fluoro-3-methyl-1H-indol-1 -yl)-N-(6-methoxypyridin-3-yl)azetidine-1-carbimidothioate → 1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)azetidin-3-yl)-5-fluoro-3-methyl-1H-indole

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 70 ℃; for 3h;

upstream raw materials:

ethyl 2-ethoxyethanoate

Downstream raw materials:

ethoxy-acetyl azide