1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid

Base Information

• Chemical Name: 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid
• CAS No.: 1605320-77-1
• Molecular Formula: C₁₅H₂₇NO₇P₂
• Molecular Weight: 395.329
• Mol file: 1605320-77-1.mol

Synonyms:1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid

Chemical Property of 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid

There total 2 articles about 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

O,O,O,O-tetra(trimethylsilyl)-1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)methylenediphosphonate (1605320-76-0) → 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid (1605320-77-1)

Guidance literature:

With methanol; In diethyl ether; at 10 ℃; Heating;

DOI:10.1134/S1070363214030347

Reference yield:

3,5-di(tert-butyl)-4-hydroxybenzoic ethyl acid imino ester hydrochloride (84654-55-7) → 1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylenediphosphonic acid (1605320-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 40 °C / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: methanol / diethyl ether / 10 °C / Reflux; Inert atmosphere

With methanol; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane;

DOI:10.1002/hc.21220

upstream raw materials:

O,O,O,O-tetra(trimethylsilyl)-1-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)methylenediphosphonate

3,5-di(tert-butyl)-4-hydroxybenzoic ethyl acid imino ester hydrochloride