{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

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Chemical Name:{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester
CAS No.:322765-91-3
Molecular Formula:C₅₃H₅₃Cl₆NO₁₃
Molecular Weight:1124.72
Hs Code.:

{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1<i>H</i>-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

Synonyms:{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of {3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

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Technology Process of {3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

There total 6 articles about {3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 322765-94-6
2-bromo-2-(3,4-dimethoxyphenyl)acetic acid-2,2,2-trichloroethyl ester

: 322765-90-2
3,4-bis(3,4-dimethoxyphenyl)-1-(4-methoxyphenethyl)-1H-pyrrole

: 322765-91-3
{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With acidic form of alumina; In dichloromethane; at 20 - 65 ℃;
DOI:10.1021/ol101644g

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 322765-91-3
{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DCC; DMAP / CH₂Cl₂ / 15 h / 15 °C

2: NBS; AIBN / CCl₄ / 1 h / 35 °C / Irradiation

3: 57 percent / acidic Al₂O₃ / CHCl₃ / 10 h / Heating

With dmap; aluminum oxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); dicyclohexyl-carbodiimide; In tetrachloromethane; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(00)01614-2

Reference yield:

: 2460-33-5
3,4-dimethoxyphenylpyruvic acid

: 322765-91-3
{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: I₂ / tetrahydrofuran / -78 - 25 °C

2.1: 4 Angstroem mol. sieves / tetrahydrofuran / 18 h

3.1: 95 percent / TFA / CHCl₃ / 10 h / Heating

4.1: 57 percent / acidic Al₂O₃ / CHCl₃ / 10 h / Heating

With aluminum oxide; n-butyllithium; 4 A molecular sieve; trifluoroacetic acid; In tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4039(00)01614-2