diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

Base Information

Chemical Name:diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate
CAS No.:1370002-31-5
Molecular Formula:C₂₄H₂₉O₈P
Molecular Weight:476.463
Hs Code.:

Synonyms:diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

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Chemical Property of diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

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Technology Process of diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

There total 3 articles about diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 78-38-6
ethylphosphonic acid diethyl ester

: 1370002-30-4
methyl 4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carboxylate

: 1370002-31-5
diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

Guidance literature:: ethylphosphonic acid diethyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

methyl 4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-carboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ja300900p

Reference yield:

: 187404-37-1
2-iodo-3,5-dimethyoxyphenol

: 1370002-31-5
diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.08 h / 0 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: carbon tetrabromide; palladium diacetate; sodium hydrogencarbonate / 20.17 h / 25 °C / 760.05 Torr

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; ethylmagnesium bromide; palladium diacetate; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; hexane; 1.1: Kumada coupling reaction / 1.2: Kumada coupling reaction;
DOI:10.1021/ja300900p

Reference yield:

: 500-99-2
3,5-dimethoxyphenol

: 1370002-31-5
diethyl {2-[4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3-yl]-1-methyl-2-oxoethyl}phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; iodine / water / 1 h / 20 °C

2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.08 h / 0 °C / Inert atmosphere

2.2: 2 h / Reflux; Inert atmosphere

3.1: carbon tetrabromide; palladium diacetate; sodium hydrogencarbonate / 20.17 h / 25 °C / 760.05 Torr

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; ethylmagnesium bromide; dihydrogen peroxide; iodine; palladium diacetate; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; hexane; water; 2.1: Kumada coupling reaction / 2.2: Kumada coupling reaction;
DOI:10.1021/ja300900p