cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Name:cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1621508-02-8
Molecular Formula:C₂₁H₃₀N₄O₄
Molecular Weight:402.494
Hs Code.:

Synonyms:cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Property of cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Technology Process of cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 19 articles about cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1621507-94-5
2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

: 13248-54-9
cyclohexyl chloroformate

: 1621508-02-8
cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1621508-07-3
tert-butyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1621508-02-8
cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With boron trifluoride diethyl etherate; triethylamine; In dichloromethane;

Reference yield:

: 1621508-30-2
tert-butyl 2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)carbamoyl)-2-(hydroxymethyl)-5-methylpyrrolidine-1-carboxylate

: 1621508-02-8
cyclohexyl 2-(2-hydroxy-1-(pyrimidin-2-yl)propyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C

3: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;