[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

Base Information

Chemical Name:[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid
CAS No.:917023-91-7
Molecular Formula:C₃₆H₄₄O₃
Molecular Weight:524.744
Hs Code.:

Synonyms:[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

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Chemical Property of [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

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Technology Process of [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

There total 9 articles about [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917026-26-7
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester

: 917023-91-7
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester; With sodium hydroxide; water; In methanol; at 100 ℃; for 0.0833333h; Irradiation;

With ammonium chloride; In methanol; water;

Reference yield:

: 865235-91-2
4-[1-ethyl-1-(4-ethynyl-3-methylphenyl)-propyl]-2-methylphenol

: 917023-91-7
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.25 h / 100 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 140 - 150 °C / Irradiation

6.1: sodium hydroxide; water / methanol / 0.08 h / 100 °C / Irradiation

With sodium hydroxide; potassium phosphate; n-butyllithium; water; potassium acetate; sodium hexamethyldisilazane; sodium bis(2-methoxyethoxy)aluminium dihydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917023-91-7
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 110 °C

1.2: pH 7

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.25 h / 100 °C

7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 140 - 150 °C / Irradiation

8.1: sodium hydroxide; water / methanol / 0.08 h / 100 °C / Irradiation

With sodium hydroxide; potassium phosphate; n-butyllithium; tetrabutyl ammonium fluoride; water; potassium acetate; sodium hexamethyldisilazane; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;