6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

Base Information

Chemical Name:6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline
CAS No.:182217-62-5
Molecular Formula:C₂₄H₂₅N₃O₅
Molecular Weight:435.48
Hs Code.:

Synonyms:6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

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Chemical Property of 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

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Technology Process of 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

There total 6 articles about 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 199456-59-2
4-{1-(Dimethyl-hydrazonomethyl)-2-[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-quinazolin-6-yl]-ethyl}-benzoic acid methyl ester

: 182217-62-5
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

Guidance literature:: With phosphate buffer; copper dichloride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/S0968-0896(97)00120-X

Reference yield:

: 4-carbomethoxy phenylacetaldehyde enamine

: 58677-07-9
N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

: 182217-62-5
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

Guidance literature:: With magnesium oxide; In methanol; dichloromethane;

Reference yield:

: 58677-07-9
N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

: 182217-62-5
6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, HMPA, -78 deg C, 6 h

2: 69 percent / aq. CuCl₂, phosphate buffer / tetrahydrofuran / 1 h / 0 °C

With phosphate buffer; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0968-0896(97)00120-X