(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

Base Information

Chemical Name:(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate
CAS No.:1176235-11-2
Molecular Formula:C₃₄H₃₄N₂O₃S
Molecular Weight:550.722
Hs Code.:

Synonyms:(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

Suppliers and Price of (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

Chemical Property:

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Technology Process of (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

There total 2 articles about (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 115545-85-2
(S)-2-amino-3-(tritylmercapto)propionic acid methyl ester

: 1552-96-1,5676-65-3
p-dimethylaminocinnamic acid

: 1176235-11-2
(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.050

Reference yield:

: 2799-07-7,25683-09-4,25840-82-8
(S)-trityl-D-cysteine

: 1176235-11-2
(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 408 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.03.050

Reference yield:

: 1176235-11-2
(S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate

: 1176235-13-4
C₁₅H₁₈N₂O₂S

: C₁₅H₁₈N₂O₂S

Guidance literature:: With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; at 20 ℃; for 0.666667h; Overall yield = 71 %; Overall yield = 44.2 mg; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.050