tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

Base Information

Chemical Name:tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)
CAS No.:229023-88-5
Molecular Formula:C₃₉H₄₇ClN₄O₈
Molecular Weight:735.277
Hs Code.:

Synonyms:tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

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Chemical Property of tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

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Technology Process of tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

There total 1 articles about tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: H-Pro-OBg

: 229023-88-5
tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given; Multistep reaction; 1.) CH₂Cl₂, 10 min, 2.) CH₂Cl₂, RT, 2 h;
DOI:10.1021/jm980442+

Reference yield: 100.0%

: 229023-88-5
tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

: 229023-89-6
Boc-Lys(2-Cl-Z)-Pro-OH

Guidance literature:: With water; potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm980442+

Reference yield:

: 229023-88-5
tert-butyloxycarbonyl-Lys(2-chlorobenzyloxycarbonyl)-Pro-O-(N-benzylhydryl-glycolamide ester)

: C₄₂H₅₃ClN₁₀O₁₀*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / K₂CO₃, water / dimethylformamide / Ambient temperature

2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, 10 min, 2.) CH₂Cl₂, THF, RT, 3 h

3: 100 percent / K₂CO₃, water / dimethylformamide / 1.5 h / Ambient temperature

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, 10 min, 2.) CH₂Cl₂

5: 1 h / Ambient temperature

With 4-methyl-morpholine; water; potassium carbonate; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm980442+