(R)-(-)-4,12-BIS(DIPHENYLPHOSPHINO)-[2.2]-PARACYCLOPHANE

Base Information

• Chemical Name: (R)-(-)-4,12-BIS(DIPHENYLPHOSPHINO)-[2.2]-PARACYCLOPHANE
• CAS No.: 192463-40-4
• Molecular Formula: C40H34 P2
• Molecular Weight: 576.657
• Mol file: 192463-40-4.mol

Synonyms:Phosphine,tricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene-5,11-diylbis[diphenyl-,stereoisomer (9CI); (S)-Phanephos; (Sp)-Phanephos

Chemical Property of (R)-(-)-4,12-BIS(DIPHENYLPHOSPHINO)-[2.2]-PARACYCLOPHANE

Chemical Property:

• Melting Point: 222-225°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 27.18000
• Density: g/cm³
• LogP: 7.08680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95%,99%ee ^*data from raw suppliers

(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane, min. 95% (S)-PHANEPHOS ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-37
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Efficient ligand for asymmetric hydrogentation of dehydroamino acids, methyl esters and keytones.

Technology Process of (R)-(-)-4,12-BIS(DIPHENYLPHOSPHINO)-[2.2]-PARACYCLOPHANE

There total 3 articles about (R)-(-)-4,12-BIS(DIPHENYLPHOSPHINO)-[2.2]-PARACYCLOPHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-4,12-bis(diphenylphosphinyl)[2.2]paracyclophane → 4,12-bis(diphenylphosphino)-[2.2]-paracyclophane (364732-88-7,192463-40-4,344905-94-8)

Guidance literature:

With trichlorosilane; In xylene; at 140 ℃;

DOI:10.1021/ja970654g

Reference yield:

[2.2]Paracyclophan (1633-22-3) → 4,12-bis(diphenylphosphino)-[2.2]-paracyclophane (364732-88-7,192463-40-4,344905-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂, Fe / CH₂Cl₂; CCl₄

3: HSiCl₃ / xylene / 140 °C

With trichlorosilane; bromine; iron; In tetrachloromethane; dichloromethane; xylene;

DOI:10.1021/ja970654g

Reference yield:

4,16-dibromo[2.2]paracyclophane (196316-30-0,196316-31-1,23927-40-4,96392-77-7) → 4,12-bis(diphenylphosphino)-[2.2]-paracyclophane (364732-88-7,192463-40-4,344905-94-8)

Guidance literature:

Multi-step reaction with 2 steps

2: HSiCl₃ / xylene / 140 °C

With trichlorosilane; In xylene;

DOI:10.1021/ja970654g

upstream raw materials:

[2.2]Paracyclophan

4,16-dibromo[2.2]paracyclophane

Downstream raw materials:

[((R)-(-)-4,12-bis(diphenylphosphino)-[2.2]-paracyclophane)palladium] dichloride

bis(2,9-dimethyl-1,10-phenanthroline)copper(I) hexafluorophosphate

[RuCl₂ (R)-Xyl-PhanephosCODMF]

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