isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

Base Information

Chemical Name:isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide
CAS No.:1253936-07-0
Molecular Formula:C₂₈H₂₆N₄O₂
Molecular Weight:450.54
Hs Code.:

Synonyms:isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

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Chemical Property of isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

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Technology Process of isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

There total 3 articles about isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106778-43-2
isoquinoline-6-carboxylic acid

: 1253936-75-2
C₁₈H₂₁N₃O*ClH

: 1253936-07-0
isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

Guidance literature:: isoquinoline-6-carboxylic acid; With thionyl chloride; at 85 ℃; for 24h; Sealed vial;

C₁₈H₂₁N₃O*ClH; With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 18h;

Reference yield:

: 180698-18-4
1-([1,1'-biphenyl]-2-yl)piperazine

: 1253936-07-0
isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.75 h / 20 °C

1.2: 24 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 h / 20 °C

3.1: thionyl chloride / 24 h / 85 °C / Sealed vial

3.2: 18 h / 50 °C

With hydrogenchloride; thionyl chloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1253936-74-1
C₂₃H₂₉N₃O₃

: 1253936-07-0
isoquinoline-6-carboxylic acid [2-(4-biphenyl-2-yl-piperazin-1-yl)-2-oxo-ethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 h / 20 °C

2.1: thionyl chloride / 24 h / 85 °C / Sealed vial

2.2: 18 h / 50 °C

With hydrogenchloride; thionyl chloride; In 1,4-dioxane; dichloromethane;