diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

Base Information

Chemical Name:diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate
CAS No.:127382-99-4
Molecular Formula:C₂₈H₂₉NO₄Si
Molecular Weight:471.628
Hs Code.:

Synonyms:diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

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Chemical Property of diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

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Technology Process of diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

There total 4 articles about diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 16035-50-0
trimethyl(trimethylstannanylethynyl)silane

: 127382-98-3
diphenylmethyl N-(benzyloxycarbonyl)-α-chloroglycinate

: 127382-99-4
diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

Guidance literature:: With zinc(II) chloride; In tetrahydrofuran; tetrachloromethane; for 0.5h; Heating;
DOI:10.1021/jo00302a034

Reference yield:

: 621-84-1
O-benzyl carbamate

: 127382-99-4
diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 144 h

2: 100 percent / 18 h

3: 75 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

4: 86 percent / zinc chloride / CCl₄; tetrahydrofuran / 0.5 h / Heating

With thionyl chloride; zinc(II) chloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane;
DOI:10.1021/jo00302a034

Reference yield:

: 79002-45-2,56538-57-9
N-benzyloxycarbonyl-glycine

: 127382-99-4
diphenylmethyl 2-amino-N-(benzyloxycarbonyl)-4-(trimethylsilyl)-3-butynoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 18 h

2: 75 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

3: 86 percent / zinc chloride / CCl₄; tetrahydrofuran / 0.5 h / Heating

With thionyl chloride; zinc(II) chloride; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jo00302a034