4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

Base Information

Chemical Name:4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide
CAS No.:1395886-23-3
Molecular Formula:C₁₆H₁₃ClFN₅O₂S
Molecular Weight:393.829
Hs Code.:

Synonyms:4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

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Chemical Property of 4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

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Technology Process of 4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

There total 3 articles about 4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: N-(2-chlorophenyl)-2-chloro-5-fluoropyrimidine-4-amine hydrochloride

: 63-74-1
sulfanilamide

: 1395886-23-3
4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

Guidance literature:: With potassium carbonate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tert-butyl alcohol; at 100 ℃; for 64h; Inert atmosphere;

Reference yield: 53.0%

: 2835-68-9
4-aminobenzamide

: 1395918-39-4
N⁴-(2-chlorophenyl)-2-chloro-5-fluoropyrimidine-4-amine

: 1395886-23-3
4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

Guidance literature:: With potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tert-butyl alcohol; for 64h; Reflux; Inert atmosphere; Sealed tube;
DOI:10.1021/jm300334d

Reference yield:

: 95-51-2
o-chloroaniline

: 1395886-23-3
4-((4-((2-chlorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 120 h / 20 °C

2: potassium carbonate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tert-butyl alcohol / 64 h / 100 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; tert-butyl alcohol;