3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid
CAS No.:1445878-73-8
Molecular Formula:C₃₃H₃₇N₅O₆S
Molecular Weight:631.753
Hs Code.:

Synonyms:3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

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Chemical Property of 3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

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Technology Process of 3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

There total 8 articles about 3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

: 1445879-96-8
3-({7-bromo-3-[(cyclohexylamino)sulfonyl]-4-quinolinyl}amino)-5-cyclopentylbenzoic acid

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445878-73-8
3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 125 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445878-73-8
3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 0.5 h / 0 °C

4: acetic acid / 24 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 850036-28-1
cyclopenten-1-ylboronic acid

: 1445878-73-8
3-{[3-(cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 145 °C / Microwave irradiation

1.2: Inert atmosphere

2.1: acetic acid / 24 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;