2'-C-β-fluoromethyluridine

Base Information

Chemical Name:2'-C-β-fluoromethyluridine
CAS No.:510765-51-2
Molecular Formula:C₁₀H₁₃FN₂O₆
Molecular Weight:276.221
Hs Code.:

Synonyms:2'-C-β-fluoromethyluridine

Suppliers and Price of 2'-C-β-fluoromethyluridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-C-β-fluoromethyluridine

Chemical Property:

Purity/Quality:

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Technology Process of 2'-C-β-fluoromethyluridine

There total 1 articles about 2'-C-β-fluoromethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 510765-51-2
2'-C-β-fluoromethyluridine

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 12 h / Reflux

2.1: tetrahydrofuran / 1 h / -78 - 30 °C

2.2: 12 h / 20 °C

3.1: NOBSA / acetonitrile / 1.5 h / Reflux

3.2: 12 h / 60 - 70 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

5.1: methanol; sodium methylate / dichloromethane / 2.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 12 h / 20 °C

7.1: water; 4-methylmorpholine N-oxide; osmium(VIII) oxide / tetrahydrofuran / 24 h / 20 °C

8.1: sodium periodate / tetrahydrofuran; methanol; water / 2 h / 20 °C

8.2: 0.5 h / 0 - 20 °C

9.1: dmap / dichloromethane / 0.67 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 72 h / 70 - 80 °C

11.1: ammonium cerium (IV) nitrate / acetonitrile; water / 20 °C

12.1: boron trichloride / dichloromethane / 2 h / -70 °C

With methanol; dmap; sodium periodate; osmium(VIII) oxide; ammonium cerium (IV) nitrate; tetrabutyl ammonium fluoride; water; sodium methylate; boron trichloride; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield: 29.0%

: 1334513-06-2
(S)-2-[(R)-(2-chloro-4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

: 510765-51-2
2'-C-β-fluoromethyluridine

: C₂₂H₂₉FN₃O₁₀P

Guidance literature:: With tert-butylmagnesium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 18h;

Reference yield:

: 510765-51-2
2'-C-β-fluoromethyluridine

: 1613591-16-4
C₂₄H₁₉F₂IN₂O₇

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; pyridine; iodine / 12 h / 0 - 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; acetonitrile / 2 h / 60 - 70 °C

3: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 0 - 20 °C

4: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With pyridine; dmap; N-iodo-succinimide; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;