4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid

Base Information

• Chemical Name: 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid
• CAS No.: 855482-38-1
• Molecular Formula: C₃₆H₄₅NO₇
• Molecular Weight: 603.756

Synonyms:4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid

Chemical Property of 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid

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Technology Process of 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid

There total 2 articles about 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H56N2O8S + 1-pentylsulfonamide (52960-14-2) → 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid (855482-38-1)

Guidance literature:

C₄₁H₅₆N₂O₈S; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-pentylsulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 4h;

Reference yield:

→ 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid (855482-38-1)

Guidance literature:

Reference yield:

4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid (855482-38-1) + 1-pentylsulfonamide (52960-14-2) → C41H56N2O8S

Guidance literature:

4'-[2-[(tert-butoxycarbonyl)[(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino)ethyl]-3-isopropoxy-4-biphenylcarboxylic acid; With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

1-pentylsulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In DMF (N,N-dimethyl-formamide); at 20 - 70 ℃; for 4h; Product distribution / selectivity;

upstream raw materials:

1-pentylsulfonamide

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