methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

Base Information

Chemical Name:methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate
CAS No.:1421253-89-5
Molecular Formula:C₂₆H₂₄N₂O₄S
Molecular Weight:460.554
Hs Code.:

Synonyms:methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

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Chemical Property of methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

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Technology Process of methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

There total 4 articles about methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421252-96-1
3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole

: 1421253-89-5
methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / N,N-dimethyl-formamide / 6 h / 110 °C

2: bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; cesium fluoride; In N,N-dimethyl-formamide;

Reference yield:

: 475039-81-7
4-bromo-3-methyl-1H-indole

: 1421253-89-5
methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 1 h

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / N,N-dimethyl-formamide / 6 h / 110 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,6-di-tert-butyl-4-methyl-phenol; potassium acetate; sodium hydride; cesium fluoride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1421254-71-8
4-bromo-3-methyl-1-tosyl-1H-indole

: 1421253-89-5
methyl 4-methyl-6-(3-methyl-1-tosyl-1H-indol-4-yl)-2-vinylnicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / N,N-dimethyl-formamide / 6 h / 110 °C

3: bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,6-di-tert-butyl-4-methyl-phenol; potassium acetate; cesium fluoride; In dimethyl sulfoxide; N,N-dimethyl-formamide;