N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

Base Information

Chemical Name:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide
CAS No.:1318757-11-7
Molecular Formula:C₁₆H₁₇ClFN₃O₃S₂
Molecular Weight:417.913
Hs Code.:

Synonyms:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

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Chemical Property of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

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Technology Process of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

There total 8 articles about N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1318757-07-1
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-2-(4-methoxyphenyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

: 1318757-11-7
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: With ammonium cerium (IV) nitrate; water; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 493038-93-0
(3-chloro-5-fluorophenyl)acetonitrile

: 1318757-11-7
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / ethanol / 72 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 3 h

4.1: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

5.2: 20 °C / pH 10 - 11

5.3: 1.5 h / 60 °C

6.1: water; ammonium cerium (IV) nitrate / acetonitrile / 1 h / 20 °C

With pyridine; hydrogenchloride; ammonium cerium (IV) nitrate; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate; acetonitrile;

Reference yield:

: 1318758-20-1
ethyl 2-(4-methoxyphenyl)-1,2-thiazinane-6-carboxylate 1,1-dioxide

: 1318757-11-7
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / methanol / 0.5 h / 20 °C

1.2: pH <= 2

2.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

2.2: 20 °C / pH 10 - 11

2.3: 1.5 h / 60 °C

3.1: water; ammonium cerium (IV) nitrate / acetonitrile / 1 h / 20 °C

With hydrogenchloride; ammonium cerium (IV) nitrate; water; potassium hydroxide; In methanol; ethanol; water; acetonitrile;