2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Base Information

Chemical Name:2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester
CAS No.:1168133-82-1
Molecular Formula:C₁₉H₂₆F₃NO₃
Molecular Weight:373.416
Hs Code.:

Synonyms:2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Suppliers and Price of 2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

There total 8 articles about 2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1168133-81-0
2-(4-cyclopropylmethoxy-3-nitro-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

: 1168133-82-1
2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 4h; under 1861.78 Torr;

Reference yield:

: 10203-58-4
(2-methylpropyl)-propanedioic acid, diethyl ester

: 1168133-82-1
2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

1.2: 48 h / 20 °C

2.1: acetic acid; sulfuric acid / water / 72 h / Reflux

3.1: sulfuric acid / Reflux

4.1: water; tin(ll) chloride / ethanol / 4 h / Reflux

5.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 °C

5.2: 0.08 h

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 48 h / 20 °C

7.1: hydrogenchloride; hydrogen; palladium on activated charcoal / water; ethanol / 4 h / 1861.78 Torr

With hydrogenchloride; sulfuric acid; palladium on activated charcoal; water; hydrogen; sodium hydride; acetic acid; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 118-83-2
5-chloro-2-nitrotrifluoromethylbenzene

: 1168133-82-1
2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C

1.2: 48 h / 20 °C

2.1: acetic acid; sulfuric acid / water / 72 h / Reflux

3.1: sulfuric acid / Reflux

4.1: water; tin(ll) chloride / ethanol / 4 h / Reflux

5.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 °C

5.2: 0.08 h

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 48 h / 20 °C

7.1: hydrogenchloride; hydrogen; palladium on activated charcoal / water; ethanol / 4 h / 1861.78 Torr

With hydrogenchloride; sulfuric acid; palladium on activated charcoal; water; hydrogen; sodium hydride; acetic acid; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;