N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Base Information

Chemical Name:N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide
CAS No.:264903-66-4
Molecular Formula:C₁₈H₂₃N₃O₆
Molecular Weight:377.397
Hs Code.:

Synonyms:N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Suppliers and Price of N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

There total 5 articles about N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 264903-65-3
N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-(carbomethoxy)acetamide

: 264903-66-4
N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Guidance literature:: With potassium hydride; Methanesulfonyl azide; In 1,2-dimethoxyethane; at 0 ℃; for 4h;
DOI:10.3987/com-99-8805

Reference yield:

: 95422-24-5
methyl (3S)-3,4-O-isopropylidene-3,4-dihydroxybutanoate

: 264903-66-4
N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / aq. NaOH / acetone / 0.75 h / 0 - 20 °C

2: 86 percent / DMAP; DCC / CH₂Cl₂ / 0 - 20 °C

3: 98 percent / LiAlH₄ / tetrahydrofuran / 17 h / Heating

4: 73 percent / DCC; DMAP / CH₂Cl₂ / 0 - 20 °C

5: 81 percent / KH in oil; methanesulfonyl azide / 1,2-dimethoxy-ethane / 4 h / 0 °C

With dmap; sodium hydroxide; lithium aluminium tetrahydride; potassium hydride; Methanesulfonyl azide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.3987/com-99-8805

Reference yield:

: 87319-12-8
(S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetic acid

: 264903-66-4
N-[{(S)-3,4-dihydroxy-3,4-O-isopropylidene}butyl]-N-(4-methoxyphenyl)-α-carbomethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DMAP; DCC / CH₂Cl₂ / 0 - 20 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 17 h / Heating

3: 73 percent / DCC; DMAP / CH₂Cl₂ / 0 - 20 °C

4: 81 percent / KH in oil; methanesulfonyl azide / 1,2-dimethoxy-ethane / 4 h / 0 °C

With dmap; lithium aluminium tetrahydride; potassium hydride; Methanesulfonyl azide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.3987/com-99-8805