2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

Base Information

Chemical Name:2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid
CAS No.:1353971-29-5
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

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Chemical Property of 2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

Chemical Property:

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Technology Process of 2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

There total 5 articles about 2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1391608-89-1
2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid methyl ester

: 1353971-29-5
2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

Guidance literature:: 2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=4;

Reference yield:

: 1391608-88-0
2'-(3-bromo-phenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid methyl ester

: 1353971-29-5
2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 6 h / 80 °C

2.2: pH 4

With copper(l) iodide; N,N-dimethylglycine hydrochoride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1353971-29-5
2'-(3-morpholinophenyl)-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-quinoline]-6'-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

2.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 16 h / 80 °C / sealed tube

3.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 6 h / 80 °C

4.2: pH 4

With copper(l) iodide; N,N-dimethylglycine hydrochoride; potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene; acetonitrile;