[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

Base Information

Chemical Name:[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol
CAS No.:386766-63-8
Molecular Formula:C₂₄H₃₅NO₂Si
Molecular Weight:397.633
Hs Code.:

Synonyms:[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

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Chemical Property of [(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

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Technology Process of [(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

There total 5 articles about [(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 386766-63-8
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / dioxane; H₂O / 24 h / 20 °C

2.1: imidazole / dimethylformamide / 48 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: HMPA / tetrahydrofuran / 0.33 h / -78 °C

4.1: LAH / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; lithium aluminium tetrahydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-17454

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 386766-63-8
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 48 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: HMPA / tetrahydrofuran / 0.33 h / -78 °C

3.1: LAH / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-17454

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 386766-63-8
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: SOCl₂ / 24 h / 0 - 20 °C

2.1: Et₃N / dioxane; H₂O / 24 h / 20 °C

3.1: imidazole / dimethylformamide / 48 h / 20 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 °C

4.2: HMPA / tetrahydrofuran / 0.33 h / -78 °C

5.1: LAH / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; lithium aluminium tetrahydride; thionyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-17454