5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

Base Information

Chemical Name:5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid
CAS No.:1204130-30-2
Molecular Formula:C₂₂H₂₃F₂N₃O₅
Molecular Weight:447.439
Hs Code.:

Synonyms:5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

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Chemical Property of 5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

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Technology Process of 5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

There total 1 articles about 5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1204130-28-8
C₂₃H₃₂BF₂NO₅

: 1204130-30-2
5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

Guidance literature:: 5-bromo-2-pyrimidinecarboxylic acid; C₂₃H₃₂BF₂NO₅; With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1204130-30-2
5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid

: C₂₆H₃₁F₂N₅O₅

Guidance literature:: 5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid; With HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

4-HYDROXYPIPERIDINE; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;