2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester

Base Information

• Chemical Name: 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester
• CAS No.: 94771-84-3
• Molecular Formula: C₂₀H₂₃NO₄S
• Molecular Weight: 373.473
• Mol file: 94771-84-3.mol

Synonyms:2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester

Chemical Property of 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester

There total 3 articles about 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-Methyl-N-[1-p-tolyl-meth-(Z)-ylidene]-benzenesulfonamide (75159-10-3) + ethyl acrylate (140-88-5,9003-32-1) → 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester (94771-84-3)

Guidance literature:

1,4-diaza-bicyclo[2.2.2]octane; at 80 ℃; for 17h;

DOI:10.1016/S0040-4039(01)81730-5

Reference yield: 72.0%

(E)-N-4-methylbenzylidene-4-toluenesulfonamide (75159-10-3) + ethyl acrylate (140-88-5,9003-32-1) → 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester (94771-84-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; at 80 ℃; for 17h;

DOI:10.1071/CH9951535

Reference yield: 29.0%

N-(4-methylbenzylidene)-p-toluenesulfonamide (75159-10-3) + ethyl acrylate (140-88-5,9003-32-1) → 2-[(Toluene-4-sulfonylamino)-p-tolyl-methyl]-acrylic acid ethyl ester (94771-84-3)

Guidance literature:

(1,3,5-triaza-7-phosphaadamantane); In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/adsc.200700071

upstream raw materials:

4-Methyl-N-[1-p-tolyl-meth-(Z)-ylidene]-benzenesulfonamide

ethyl acrylate

(E)-N-4-methylbenzylidene-4-toluenesulfonamide

N-(4-methylbenzylidene)-p-toluenesulfonamide

Downstream raw materials:

3t-p-tolyl-2-benzyl-acrylic acid ethyl ester