4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

Base Information

Chemical Name:4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide
CAS No.:1227477-33-9
Molecular Formula:C₂₂H₁₇Cl₃N₂O₃
Molecular Weight:463.748
Hs Code.:

Synonyms:4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

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Chemical Property of 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

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Technology Process of 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

There total 4 articles about 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227476-93-8
BrH*C₂₂H₁₇Cl₃N₂O₃

: 1227477-33-9
4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.08.029

Reference yield:

: 58622-66-5
4-chloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide

: 1227477-33-9
4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 4 h / -10 °C

2: hydrogen bromide; acetic acid / 0.5 h / 20 °C

3: triethylamine / chloroform / 0.5 h / 20 °C

With hydrogen bromide; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.08.029

Reference yield:

: 5106-98-9
4-chlorosalicylic acid

: 1227477-33-9
4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-1-oxo-3-phenylpropan-2-yl}-2-hydroxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus trichloride / chlorobenzene / 0.33 h / Microwave irradiation

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 4 h / -10 °C

3: hydrogen bromide; acetic acid / 0.5 h / 20 °C

4: triethylamine / chloroform / 0.5 h / 20 °C

With hydrogen bromide; acetic acid; triethylamine; dicyclohexyl-carbodiimide; phosphorus trichloride; In chloroform; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1016/j.bmc.2013.08.029