5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Base Information

Chemical Name:5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide
CAS No.:1352570-07-0
Molecular Formula:C₂₀H₂₁N₅O₄
Molecular Weight:395.418
Hs Code.:

Synonyms:5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Suppliers and Price of 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

There total 10 articles about 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉N₅O₅

: 1352570-07-0
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.166667h;

Reference yield:

: 68792-12-1
3-isopropoxyphenol

: 1352570-07-0
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere; Sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

5: caesium carbonate; copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / N,N-dimethyl acetamide / 120 °C / Sealed tube

6: trifluoroacetic acid / dichloromethane / 0.17 h

With 1H-imidazole; 2,2,6,6-tetramethylheptane-3,5-dione; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; trifluoroacetic acid; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; water; 3: Suzuki Coupling;

Reference yield:

: 108-46-3
recorcinol

: 1352570-07-0
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere; Sealed tube

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

6: caesium carbonate; copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / N,N-dimethyl acetamide / 120 °C / Sealed tube

7: trifluoroacetic acid / dichloromethane / 0.17 h

With 1H-imidazole; 2,2,6,6-tetramethylheptane-3,5-dione; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; caesium carbonate; trifluoroacetic acid; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 4: Suzuki Coupling;