Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester
• CAS No.: 144852-32-4
• Molecular Formula: C₁₉H₂₄N₂O₂
• Molecular Weight: 312.412
• Mol file: 144852-32-4.mol

Synonyms:Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester

Chemical Property of Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester

There total 3 articles about Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

((S)-1-Cyano-2-methyl-butyl)-methyl-carbamic acid benzyl ester (144852-28-8) + acetylene (74-86-2,25067-58-7) → Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester (144852-32-4)

Guidance literature:

(η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene; at 110 ℃; for 72h; under 10640 Torr;

DOI:10.1055/s-1992-26282

Reference yield:

((S)-1-Carbamoyl-2-methyl-butyl)-methyl-carbamic acid benzyl ester (144852-25-5) → Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester (144852-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / p-TsCl, pyridine / 3 h / Heating

2: 63 percent / CpCo(COD) / toluene / 72 h / 110 °C / 10640 Torr

With pyridine; p-toluenesulfonyl chloride; (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene;

DOI:10.1055/s-1992-26282

Reference yield:

(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-pentanoic acid (42417-66-3,42417-67-4,130199-62-1) → Methyl-((S)-2-methyl-1-pyridin-2-yl-butyl)-carbamic acid benzyl ester (144852-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) 4-methylmorpholine, ethyl chloroformate, 2) 25percent aq. NH₃ / 1) THF, -15 deg C, 10 min, 2) THF, r.t., 12 h

2: 70 percent / p-TsCl, pyridine / 3 h / Heating

3: 63 percent / CpCo(COD) / toluene / 72 h / 110 °C / 10640 Torr

With 4-methyl-morpholine; pyridine; ammonium hydroxide; chloroformic acid ethyl ester; p-toluenesulfonyl chloride; (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene;

DOI:10.1055/s-1992-26282

upstream raw materials:

((S)-1-Cyano-2-methyl-butyl)-methyl-carbamic acid benzyl ester

acetylene

((S)-1-Carbamoyl-2-methyl-butyl)-methyl-carbamic acid benzyl ester

(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-pentanoic acid