[tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate

Base Information

• Chemical Name: [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate
• CAS No.: 362663-64-7
• Molecular Formula: C₁₈H₂₇NO₆
• Molecular Weight: 353.415
• Mol file: 362663-64-7.mol

Synonyms:[tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate

Chemical Property of [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate

There total 2 articles about [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,N-di(tert-butoxycarbonyl)hydroxylamine (85006-25-3) + p-methoxybenzyl chloride (824-94-2) → [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate (362663-64-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate (362663-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine / water; n-heptane; tert-butyl methyl ether / -5 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium carbonate; triethylamine; In n-heptane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;

Reference yield: 81.0%

[tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate (362663-64-7) → N-[(4-methoxyphenyl)methyl]hydroxylamine hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

N,N-di(tert-butoxycarbonyl)hydroxylamine

p-methoxybenzyl chloride

di-tert-butyl dicarbonate

Downstream raw materials:

N-(4-methoxybenzyl)hydroxylamine