2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Base Information

Chemical Name:2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide
CAS No.:1383843-27-3
Molecular Formula:C₂₅H₂₂ClN₃O₅S
Molecular Weight:511.986
Hs Code.:

Synonyms:2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

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Chemical Property of 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

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Technology Process of 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

There total 6 articles about 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1383842-99-6
2-(1-(4-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

: 1383843-27-3
2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: C₁₉H₁₅Cl₂NO₂S

: 1383843-27-3
2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

: 2-methyl-5-(methylthio)-3-(phenylthio)indole

: 1383843-27-3
2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Thiosalicylic acid; trifluoroacetic acid / 0.5 h / 20 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 24 h / 20 °C

2.2: 0.17 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With Thiosalicylic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; In dichloromethane; dimethyl sulfoxide;