{(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

Base Information

Chemical Name:{(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol
CAS No.:1422129-09-6
Molecular Formula:C₁₅H₁₅F₆NO
Molecular Weight:339.281
Hs Code.:

Synonyms:{(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

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Chemical Property of {(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

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Technology Process of {(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

There total 2 articles about {(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185561-91-5
(1R,5S,6r)-3-azabicyclo[3.1.0]hex-6-ylmethanol hydrochloride

: 32890-87-2
2,4-bis(trifluoromethyl)benzoic acid

: 1422129-09-6
{(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

Guidance literature:: (1R,5S,6r)-3-azabicyclo[3.1.0]hex-6-ylmethanol hydrochloride; 2,4-bis(trifluoromethyl)benzoic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1422130-51-5
[(1R,5S,6r)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]methanol hydrochloride

: 1422129-09-6
{(1R,5S,6r)-3-[2,4-bis(trifluoromethyl)benzyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 50 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; N,N-dimethyl-formamide;