3-FLUORO-5-HYDROXYBENZENEBORONIC ACID

Base Information

• Chemical Name: 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
• CAS No.: 871329-82-7
• Molecular Formula: C6H6BFO3
• Molecular Weight: 155.921
• Hs Code.: 2931900090
• Mol file: 871329-82-7.mol

Synonyms:Boronicacid, (3-fluoro-5-hydroxyphenyl)- (9CI);(3-Fluoro-5-hydroxyphenyl)boronic acid;

Chemical Property of 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID

Chemical Property:

• Vapor Pressure: 1.89E-06mmHg at 25°C
• Melting Point: 54-62 °C
• Refractive Index: 1.552
• Boiling Point: 380 °C at 760 mmHg
• PKA: 7.23±0.10(Predicted)
• Flash Point: 183.6 °C
• PSA: 60.69000
• Density: 1.42 g/cm³
• LogP: -0.78890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-5-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction 3-Fluoro-5-hydroxybenzeneboronic acid is used as pharmaceutical intermediate.

Technology Process of 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID

There total 1 articles about 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-5-methoxyphenylboronic acid (609807-25-2) → (3-fluoro-5-hydroxyphenyl)boronic acid (871329-82-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h; Time; Inert atmosphere;

Reference yield: 98.0%

(3-fluoro-5-hydroxyphenyl)boronic acid (871329-82-7) + tert-butyl N-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)-N-[2-[tert-butoxycarbonyl-[2-(tert-butyl(dimethyl)silyl)oxyethyl]amino]ethyl]carbamate (1429313-21-2) → C32H48FN5O6Si

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; at 80 - 90 ℃; for 24h; Inert atmosphere;

Reference yield: 87.0%

N-[6-chloro-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide (1014720-89-8) + (3-fluoro-5-hydroxyphenyl)boronic acid (871329-82-7) → N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-(3-fluoro-5-hydroxy-phenyl)-pyrimidin-4-yl]-acetamide (1061750-32-0)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 6h;

upstream raw materials:

3-fluoro-5-methoxyphenylboronic acid

Downstream raw materials:

N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-(3-fluoro-5-hydroxy-phenyl)-pyrimidin-4-yl]-acetamide

{3-[(allylmethylamino)methyl]phenyl}-[4-(3-but-3-enyloxy-5-fluorophenyl)pyrimidin-2-yl]amine

4-(3-but-3-enyloxy-5-fluorophenyl)-2-chloropyrimidine

3-(4-amino-1-((1-phenyl-1H-benzo[d]imidazol-2-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-5-fluorophenol

Refernces