1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol

Base Information

• Chemical Name: 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol
• CAS No.: 1719-18-2
• Molecular Formula: C₂₃H₂₀O
• Molecular Weight: 312.411
• Mol file: 1719-18-2.mol

Synonyms:1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol

Chemical Property of 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol

There total 5 articles about 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(p-methylphenyl)-methanone (611-97-2) + phenylacetylene (536-74-3) → 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol (1719-18-2)

Guidance literature:

phenylacetylene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

bis(p-methylphenyl)-methanone; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/ol901981s

Reference yield:

4,4'-dimethylbenzhydrol (885-77-8) + phenylacetylene (536-74-3) → 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol (1719-18-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;

DOI:10.1021/acs.orglett.6b01875

Reference yield:

1-Phenyl-1-chlor-3,3-bis-(4-methylphenyl)-propan-dien (35476-67-6) → 1,1-di(p-methylphenyl)-3-phenylpropargyl alcohol (1719-18-2)

Guidance literature:

With (solvolysis); In water; acetone; at 25 ℃; Rate constant;

DOI:10.1021/ja00754a050

upstream raw materials:

para-methylphenylmagnesium bromide

phenylpropynoic acid ethyl ester

1-Phenyl-1-chlor-3,3-bis-(4-methylphenyl)-propan-dien

bis(p-methylphenyl)-methanone

Downstream raw materials:

methyl-(3-phenyl-1,1-di-p-tolyl-prop-2-ynyl)-ether

5,7-dimethyl-3-phenyl-1,1-dip-tolyl-1H-inden-6-ol

C₄₀H₃₁NO₃

4-phenyl-1,2-di(p-tolyl)-9H-carbazole