2-(METHYLSULFONYL)PHENOL

Base Information

• Chemical Name: 2-(METHYLSULFONYL)PHENOL
• CAS No.: 27489-33-4
• Molecular Formula: C7H8O3S
• Molecular Weight: 172.205
• Hs Code.: 2908999090
• Mol file: 27489-33-4.mol

Synonyms:2-(Methylsulfonyl)phenol;2-Hydroxyphenyl methyl sulfone;Phenol,o-(methylsulfonyl)- (6CI,7CI,8CI);o-(Methylsulfonyl)phenol;2-(Methanesulfonyl)phenol;

Chemical Property of 2-(METHYLSULFONYL)PHENOL

Chemical Property:

• Vapor Pressure: 1.2E-05mmHg at 25°C
• Melting Point: 78-84 ºC
• Refractive Index: 1.556
• Boiling Point: 358.8 °C at 760 mmHg
• PKA: 6.83±0.30(Predicted)
• Flash Point: 170.8 °C
• PSA: 62.75000
• Density: 1.328 g/cm³
• LogP: 1.87650
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Methylsulfonyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(METHYLSULFONYL)PHENOL

There total 4 articles about 2-(METHYLSULFONYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-fluoro-2-(methylsulfonyl)benzene (654-47-7) → 2-hydroxyphenyl methyl sulfone (27489-33-4)

Guidance literature:

With acetylhydroxamic acid; potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.orglett.6b00876

Reference yield: 81.0%

2-(methylsulfenyl)phenol (1073-29-6) → 2-hydroxyphenyl methyl sulfone (27489-33-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 - 25 ℃; for 18h;

DOI:10.1021/acs.joc.6b01827

Reference yield:

1-methanesulfonyl-2-methoxy-benzene (13736-79-3) → 2-hydroxyphenyl methyl sulfone (27489-33-4)

Guidance literature:

With hydrogen bromide; at 150 ℃;

DOI:10.1039/jr9380000899

upstream raw materials:

1-methanesulfonyl-2-methoxy-benzene

2-(methylsulfenyl)phenol

1-fluoro-2-(methylsulfonyl)benzene

Downstream raw materials:

1-<2-(methylsulfonyl)phenoxy>-2,3-epoxypropane

C₁₈H₁₅N₃O₆S₂

2-(methylsulfonyl)phenyl benzoate

2-[2-(methanesulfonyl)phenyl]ethan-1-ol

Refernces

• 1、 Bosset, Cyril,Lefebvre, Gauthier,Angibaud, Patrick,Stansfield, Ian,Meerpoel, Lieven,Berthelot, Didier,Guérinot, Amandine,Cossy, Janine. "Iron-Catalyzed Synthesis of Sulfur-Containing Heterocycles". . p. 4020 - 4036. Retrieved 2017/04/27.
• 2、 -. "NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE". Page/Page column 68. . Retrieved 2009/10/01.