3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 249750-75-2
• Molecular Formula: C₁₉H₁₆N₂OS₂
• Molecular Weight: 352.481

Synonyms:3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property of 3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

There total 1 articles about 3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-phenyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one (42076-13-1) + propargyl bromide (106-96-7) → 3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (249750-75-2)

Guidance literature:

3-phenyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one; With sodium hydroxide; In ethanol; water; Heating;

propargyl bromide; In ethanol; water; at 80 ℃; for 1h;

DOI:10.1515/hc-2013-0036

Reference yield: 71.0%

3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (249750-75-2) → (1E)-1-(iodomethylidene)-5-oxo-4-phenyl-1,2,4,5,6,7,8,9-octahydrobenzo[4,5]thieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-11-ium iodide

Guidance literature:

With iodine; acetic acid; at 20 ℃; for 72h; stereoselective reaction;

DOI:10.1515/hc-2013-0036

Reference yield: 64.0%

3-phenyl-2-(prop-2-yn-1-ylthio)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (249750-75-2) → (1E)-1-(bromomethylidene)-5-oxo-4-phenyl-1,2,4,5,6,7,8,9-octahydrobenzo[4,5]-thieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-11-ium bromide

Guidance literature:

With bromine; acetic acid; at 10 ℃; for 3h; stereoselective reaction;

DOI:10.1515/hc-2013-0036

upstream raw materials:

3-phenyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one

propargyl bromide

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