(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Base Information

Chemical Name:(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
CAS No.:1262441-70-2
Molecular Formula:C₁₅H₁₄FN₃OS
Molecular Weight:303.36
Hs Code.:

Synonyms:(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of (S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

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Technology Process of (S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

There total 10 articles about (S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1262441-68-8
(S)-tert-butyl 1-(6-(3-fluorophenyl)-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethylcarbamate

: 1262441-70-2
(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.75h; Concentration; Temperature;

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 1262441-70-2
(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; bromine / dichloromethane / Cooling with ice

2.1: polyphosphoric acid / 70 - 78 °C / Inert atmosphere

3.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 0.83 h

5.1: sodium iodide / methanol / 0.17 h / 20 °C

5.2: 0.33 h / 5 - 25 °C

6.1: isopropyl alcohol / 0.58 h / Reflux

7.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

9.1: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

9.2: 0 - 5 °C / pH 10

With hydrogenchloride; N-Bromosuccinimide; sodium azide; bromine; sodium hydrogencarbonate; sodium carbonate; sodium iodide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 8.1: Suzuki Coupling;

Reference yield:

: 1262441-52-0
7-(1-bromoethyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

: 1262441-70-2
(S)-7-(1-aminoethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 0.83 h

3.1: sodium iodide / methanol / 0.17 h / 20 °C

3.2: 0.33 h / 5 - 25 °C

4.1: isopropyl alcohol / 0.58 h / Reflux

5.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

7.2: 0 - 5 °C / pH 10

With hydrogenchloride; N-Bromosuccinimide; sodium azide; sodium hydrogencarbonate; sodium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 6.1: Suzuki Coupling;