di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Base Information

Chemical Name:di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate
CAS No.:1377615-92-3
Molecular Formula:C₂₉H₄₃FN₂O₆S
Molecular Weight:566.735
Hs Code.:

di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Synonyms:di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Suppliers and Price of di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

There total 8 articles about di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.76%

: 1377615-91-2
di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-azido-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methylphenyl)sulfanylmethyl]bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 1377615-92-3
di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Guidance literature:: With 1.3-propanedithiol; triethylamine; In methanol; at 20 ℃; for 18h;

Reference yield:

: di-tert-butyl (1S,2R,3S,4R,5R,6R)-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]-4-methylsulfonyloxybicyclo[3.1.0]hexane-2,6-dicarboxylate

: 1377615-92-3
di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 18 h / 100 °C

2: triethylamine; 1.3-propanedithiol / methanol / 18 h / 20 °C

With 1.3-propanedithiol; sodium azide; triethylamine; In methanol; dimethyl sulfoxide;

Reference yield:

: 1377615-79-6
di-tert-butyl (1S,2R,5R,6R)-2-(tert-butoxycarbonylamino)-3-(dimethylaminomethylene)-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 1377615-92-3
di-tert-butyl (1S,2R,3R,4S,5R,6S)-4-amino-2-(tert-butoxycarbonylamino)-3-[(4-fluoro-3-methyl-phenyl)sulfanylmethyl]bicyclo[3.1.0]-hexane-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; diisobutylaluminium hydride / hexane; tetrahydrofuran / 3.25 h / -47 °C / Inert atmosphere

1.2: -47 - 20 °C

2.1: triethylamine / diethyl ether / 0.25 h / 40 °C / Inert atmosphere

3.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / diethyl ether; tetrahydrofuran / -10 °C / Inert atmosphere

4.1: pyridine / 19 h / 0 - 40 °C

5.1: sodium azide / dimethyl sulfoxide / 18 h / 100 °C

6.1: triethylamine; 1.3-propanedithiol / methanol / 18 h / 20 °C

With pyridine; 1.3-propanedithiol; sodium azide; dimethylsulfide borane complex; diisobutylaluminium hydride; triethylamine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; hexane; dimethyl sulfoxide;