2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

Base Information

Chemical Name:2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone
CAS No.:1428972-93-3
Molecular Formula:C₁₉H₁₇ClFNO₂
Molecular Weight:345.801
Hs Code.:

Synonyms:2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

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Chemical Property of 2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

Chemical Property:

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Technology Process of 2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

There total 3 articles about 2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1428972-76-2
2-chloro-1-(5-fluoro-1H-indol-3-yl)-2-phenylethanone

: 627-18-9
1-bromo-3-propanol

: 1428972-93-3
2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1428972-93-3
2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / toluene / 2 h / 55 °C

2: potassium carbonate / N,N-dimethyl-formamide

With pyridine; potassium carbonate; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 2912-62-1
α-chlorophenylacetyl chloride

: 1428972-93-3
2-chloro-1-(5-fluoro-1-(3-hydroxypropyl)-1H-indol-3-yl)-2-phenylethanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / toluene / 2 h / 55 °C

2: potassium carbonate / N,N-dimethyl-formamide

With pyridine; potassium carbonate; In N,N-dimethyl-formamide; toluene;