BOC-D-LYS(Z)-OH

Base Information

• Chemical Name: BOC-D-LYS(Z)-OH
• CAS No.: 76477-42-4
• Molecular Formula: C₁₂H₂₃N*C₁₉H₂₈N₂O₆
• Molecular Weight: 561.762
• Mol file: 76477-42-4.mol

Synonyms:Boc-D-Lys(Z)-OH

Chemical Property of BOC-D-LYS(Z)-OH

Chemical Property:

• PSA: 125.99000
• LogP: 7.47510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-6-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-LYS(Z)-OH

There total 1 articles about BOC-D-LYS(Z)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (16948-04-2,76477-42-4)

Guidance literature:

N^ε-Benzyloxycarbonyllysin, tert.-Butyl-azidoformiat;

Reference yield:

Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (16948-04-2,76477-42-4) + L-threonine benzyl ester hydrochloride → (2S,3R)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-butyric acid benzyl ester

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield:

Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (16948-04-2,76477-42-4) + Boc-Ser-Gln-Gly-Gly-Ser-ONb → Boc-Lys(Z)-Ser-Gln-Gly-Gly-Ser-ONb

Guidance literature:

With 4-methyl-morpholine; TFA-anisole; benzotriazol-1-ol; Yield given. Multistep reaction; 1.) room temperature, 20 min 2.) DMF, overnight, 4 deg C;

DOI:10.1248/cpb.30.4448

Downstream raw materials:

N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysyl-alanyl-leucine methyl ester

Boc-Lys(Z)-Ser-Gln-Gly-Gly-OBzl

Boc-Lys(Z)-Gly-OBzl