2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Base Information

• Chemical Name: 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone
• CAS No.: 131523-26-7
• Molecular Formula: C₂₄H₂₁NO₂
• Molecular Weight: 355.436
• Mol file: 131523-26-7.mol

Synonyms:2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property of 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

There total 13 articles about 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-(4-methoxybenzyl)-3-styrylisoindolin-1-one → C24H21NO2 + 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-26-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 - 80 ℃; Overall yield = 55 percent;

DOI:10.1016/j.tet.2019.130838

Reference yield:

3-hydroxy-2-(4-methoxy-benzyl)-3-phenethyl-2,3-dihydro-isoindol-1-one → 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-26-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.5h; Yield given; Ambient temperature;

DOI:10.1248/cpb.47.529

Reference yield:

2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione (21244-24-6) → 2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

2: 15 percent aq.HCl / tetrahydrofuran / 0.5 h / Ambient temperature

With hydrogenchloride; magnesium; In tetrahydrofuran;

DOI:10.1248/cpb.47.529

upstream raw materials:

phenylacetaldehyde

2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-(4-methoxy-benzyl)-benzamide

2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione

1-phenyl-2-bromoethane

Downstream raw materials:

2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone