4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

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Chemical Name:4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin
CAS No.:155435-02-2
Molecular Formula:C₄₆H₅₁Br₃ClN₃O₁₆
Molecular Weight:1177.09
Hs Code.:

4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

Synonyms:4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

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Chemical Property of 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

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Technology Process of 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

There total 13 articles about 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 155435-03-3
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

: 155435-02-2
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

Guidance literature:: With phosgene; dmap; In dichloromethane; toluene; for 2h; Ambient temperature;
DOI:10.1039/a708132d

Reference yield:

: 72423-56-4
3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-methyl-pyrrole-2-carboxylic acid

: 155435-02-2
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 0.5 h / Ambient temperature

2: N,N-dimethylaniline / CH₂Cl₂ / 1.) room temperature, 30 min, 2.) reflux, 15 min

3: sulfuryl chloride / CH₂Cl₂ / 0.25 h

4: AcONa / 1 h / 75 °C

5: 85.5 percent / p-TsOH / CH₂Cl₂ / 2 h

6: 86 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

7: 83 percent / NaHCO₃, I, KI / CH₂Cl₂; H₂O / 0.33 h

8: stannic chloride / CH₂Cl₂ / 0.33 h

With sulfuryl dichloride; oxalyl dichloride; sodium acetate; tin(IV) chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; N,N-dimethyl-aniline; N,N-dimethyl-formamide; potassium iodide; In dichloromethane; water;

Reference yield:

: 75975-52-9
3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 155435-02-2
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-1-chloro-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin

Guidance literature:: Multi-step reaction with 4 steps

1: 85.5 percent / p-TsOH / CH₂Cl₂ / 2 h

2: 86 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

3: 83 percent / NaHCO₃, I, KI / CH₂Cl₂; H₂O / 0.33 h

4: stannic chloride / CH₂Cl₂ / 0.33 h

With tin(IV) chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; potassium iodide; In dichloromethane; water;