(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Base Information

Chemical Name:(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide
CAS No.:126394-43-2
Molecular Formula:C₂₁H₃₂O₄
Molecular Weight:348.483
Hs Code.:

Synonyms:(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Suppliers and Price of (2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

There total 16 articles about (2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 126394-42-1,126455-62-7
(3R,5S,6S)-6-[(1S,2R)-1-Ethyl-2-(4-methoxy-benzyloxy)-butyl]-3,5-dimethyl-tetrahydro-pyran-2-ol

: 126394-43-2
(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Guidance literature:: With 3 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1248/cpb.37.1698

Reference yield:

: 113643-47-3
(S)-2-((2S,3S,6S)-6-Isopropoxy-3,5-dimethyl-3,6-dihydro-2H-pyran-2-yl)-butan-1-ol

: 126394-43-2
(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / 5percent Rh-Al₂O₃ / diethyl ether / 3.5 h

2: 1) DMSO, (COCl)2, 2) Et₃N / 1) CH₂Cl₂, -70 deg C, 2) CH₂Cl₂, -70 to 0 deg C

3: diethyl ether / -50 - 0 °C

4: 1) NaH / 1) DMF, RT, 2) DMF, 50 deg C, 18 h

5: 80 percent / 0.4N HCl / tetrahydrofuran / 16 h / 55 °C

6: 94 percent / pyridinium chlorochromate, mol. sieves 3A / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; oxalyl dichloride; 3 A molecular sieve; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; rhodium on alumina; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1248/cpb.37.1698

Reference yield:

: 110653-58-2
(2R,3R,4S)-4-benzyloxymethyl-3-formyloxy-2-methylhexanal

: 126394-43-2
(2R,4S,5S,6S,7R)-6-ethyl-7-(4-methoxybenzyloxy)-2,4-dimethylnonan-5-olide

Guidance literature:: Multi-step reaction with 11 steps

1: 1) NaH / 1) THF, 0 to 20 deg C, 2) THF, -78 to -15 deg C, 3 h

2: 74 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

3: DIBAH / toluene / 0.17 h / -80 °C

4: CSA / 0.25 h / Ambient temperature

5: hydrogen / Raney Ni (W-2) / ethanol / 2 h / Ambient temperature

6: hydrogen / 5percent Rh-Al₂O₃ / diethyl ether / 3.5 h

7: 1) DMSO, (COCl)2, 2) Et₃N / 1) CH₂Cl₂, -70 deg C, 2) CH₂Cl₂, -70 to 0 deg C

8: diethyl ether / -50 - 0 °C

9: 1) NaH / 1) DMF, RT, 2) DMF, 50 deg C, 18 h

10: 80 percent / 0.4N HCl / tetrahydrofuran / 16 h / 55 °C

11: 94 percent / pyridinium chlorochromate, mol. sieves 3A / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; oxalyl dichloride; 3 A molecular sieve; camphor-10-sulfonic acid; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; rhodium on alumina; Raney Ni (W-2); In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.37.1698