N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

Base Information

Chemical Name:N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide
CAS No.:1314274-93-5
Molecular Formula:C₃₅H₃₈N₄O₅
Molecular Weight:594.711
Hs Code.:

N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

Synonyms:N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

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Chemical Property of N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

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Technology Process of N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

There total 9 articles about N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-36-7
4-phenoxy benzaldehyde

: 1314274-96-8
tert-butyl ((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-10-(isonicotinamido)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl(methyl)carbamate

: 1314274-93-5
N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

Guidance literature:: 4-phenoxy benzaldehyde; tert-butyl ((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-10-(isonicotinamido)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl(methyl)carbamate; With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 1255212-71-5
(2S,3R)-4-(tert-butoxycarbonyl(methyl)amino)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoic acid

: 1314274-93-5
N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 15 h / 3 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 65 °C / Inert atmosphere

2.2: 12 h / Reflux

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: cesium fluoride / N,N-dimethyl-formamide / 5 h / 85 °C

5.1: hydrogen / palladium on activated charcoal / ethanol / 1.5 h / 40 °C

6.1: 2,6-dimethylpyridine / dichloromethane / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 - 20 °C / pH 7

8.1: trifluoroacetic acid / dichloromethane / 20 °C

9.1: sodium tris(acetoxy)borohydride / acetic acid / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1393801-84-7
tert-butyl (((2R,3R)-10-amino-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

: 1314274-93-5
N-((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-2-((methyl(3-phenoxybenzyl)amino)methyl)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 20 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 - 20 °C / pH 7

3: trifluoroacetic acid / dichloromethane / 20 °C

4: sodium tris(acetoxy)borohydride / acetic acid / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; sodium tris(acetoxy)borohydride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; acetic acid; In dichloromethane; N,N-dimethyl-formamide;