XM 612

Base Information

Chemical Name:XM 612
CAS No.:181116-68-7
Molecular Formula:C₂₆H₄₀O₃
Molecular Weight:400.602
Hs Code.:

Synonyms:XM 612

Suppliers and Price of XM 612

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Chemical Property of XM 612

Chemical Property:

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Technology Process of XM 612

There total 18 articles about XM 612 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181116-48-3
benzyl (2S,3R)-2-methyl-3-((1S)-1-methyl-2-cyclohexenyl)butyl ether

: 181116-68-7
XM 612

Guidance literature:: Multi-step reaction with 10 steps

1.1: 9-BBN / tetrahydrofuran / 48 h / Heating

1.2: 95 percent / 30 percent H₂O₂; 6 N aq. NaOH / ethanol / 1.5 h / 55 °C

2.1: 93 percent / imidazole; DMAP / dimethylformamide / 16 h / 20 °C

3.1: cyclohexene / 20 percent Pd(OH)2/C / ethanol / 6 h / Heating

4.1: 91 percent / pyridine / 19 h / 20 °C

5.1: NaH; DMSO / 0.75 h / 20 °C

5.2: 68 percent / dimethylsulfoxide / 0.75 h

6.1: 98 percent / TBAF / tetrahydrofuran / 10 h / 20 °C

7.1: 85 percent / PDC / CH₂Cl₂ / 22 h / 20 °C

8.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8.2: 100 percent / tetrahydrofuran; hexane / 2 h / -78 °C

9.1: 100 percent / PPTS / CH₂Cl₂ / 1 h / 20 °C

10.1: 100 percent / TBAF / tetrahydrofuran / 14 h / 20 °C

With pyridine; 1H-imidazole; dmap; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; dimethyl sulfoxide; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: hydroboration / 1.2: Oxidation / 2.1: silylation / 3.1: debenzylation / 4.1: Tosylation / 5.1: Metallation / 5.2: Substitution / 6.1: desilylation / 7.1: Oxidation / 8.1: Metallation / 8.2: Condensation / 9.1: acidolysis / 10.1: desilylation;
DOI:10.1021/jm980736v

Reference yield:

: 248916-05-4
[(S)-3-((1R,2S)-3-Benzyloxy-1,2-dimethyl-propyl)-3-methyl-cyclohexyloxy]-tert-butyl-diphenyl-silane

: 181116-68-7
XM 612

Guidance literature:: Multi-step reaction with 8 steps

1.1: cyclohexene / 20 percent Pd(OH)2/C / ethanol / 6 h / Heating

2.1: 91 percent / pyridine / 19 h / 20 °C

3.1: NaH; DMSO / 0.75 h / 20 °C

3.2: 68 percent / dimethylsulfoxide / 0.75 h

4.1: 98 percent / TBAF / tetrahydrofuran / 10 h / 20 °C

5.1: 85 percent / PDC / CH₂Cl₂ / 22 h / 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

6.2: 100 percent / tetrahydrofuran; hexane / 2 h / -78 °C

7.1: 100 percent / PPTS / CH₂Cl₂ / 1 h / 20 °C

8.1: 100 percent / TBAF / tetrahydrofuran / 14 h / 20 °C

With pyridine; dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; dimethyl sulfoxide; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; 1.1: debenzylation / 2.1: Tosylation / 3.1: Metallation / 3.2: Substitution / 4.1: desilylation / 5.1: Oxidation / 6.1: Metallation / 6.2: Condensation / 7.1: acidolysis / 8.1: desilylation;
DOI:10.1021/jm980736v

Reference yield:

: (2R/S,3S)-4-benzyloxy-3-methyl-2-((1S)-1-methyl-2-cyclohexenyl)butanoic acid

: 181116-68-7
XM 612

Guidance literature:: Multi-step reaction with 13 steps

1.1: LiAlH₄ / tetrahydrofuran / 43 h / Heating

2.1: 80 percent / pyridine / 24 h / 0 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4.1: 9-BBN / tetrahydrofuran / 48 h / Heating

4.2: 95 percent / 30 percent H₂O₂; 6 N aq. NaOH / ethanol / 1.5 h / 55 °C

5.1: 93 percent / imidazole; DMAP / dimethylformamide / 16 h / 20 °C

6.1: cyclohexene / 20 percent Pd(OH)2/C / ethanol / 6 h / Heating

7.1: 91 percent / pyridine / 19 h / 20 °C

8.1: NaH; DMSO / 0.75 h / 20 °C

8.2: 68 percent / dimethylsulfoxide / 0.75 h

9.1: 98 percent / TBAF / tetrahydrofuran / 10 h / 20 °C

10.1: 85 percent / PDC / CH₂Cl₂ / 22 h / 20 °C

11.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

11.2: 100 percent / tetrahydrofuran; hexane / 2 h / -78 °C

12.1: 100 percent / PPTS / CH₂Cl₂ / 1 h / 20 °C

13.1: 100 percent / TBAF / tetrahydrofuran / 14 h / 20 °C

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; dimethyl sulfoxide; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Tosylation / 3.1: reductive cleavae / 4.1: hydroboration / 4.2: Oxidation / 5.1: silylation / 6.1: debenzylation / 7.1: Tosylation / 8.1: Metallation / 8.2: Substitution / 9.1: desilylation / 10.1: Oxidation / 11.1: Metallation / 11.2: Condensation / 12.1: acidolysis / 13.1: desilylation;
DOI:10.1021/jm980736v