(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol
CAS No.:805240-81-7
Molecular Formula:C₁₄H₂₀O₃
Molecular Weight:236.311
Hs Code.:

Synonyms:(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Suppliers and Price of (2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

There total 4 articles about (2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-dihydro-furan-3-one

: 805240-81-7
(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In acetonitrile; for 1h;
DOI:10.1021/ja047291m

Reference yield:

: 41381-33-3
1-iodo-2,3,4-trimethylbenzene

: 805240-81-7
(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: palladium acetate; triphenylarsine; tri-n-butylamine / dimethylformamide / 16 h / 70 °C

2: tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

3: 376 mg / sodium triacetoxyborohydride; AcOH / acetonitrile / 1 h

With tributyl-amine; triphenyl-arsane; tetrabutyl ammonium fluoride; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: Heck reaction;
DOI:10.1021/ja047291m

Reference yield:

: 173327-56-5
3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose

: 805240-81-7
(2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: palladium acetate; triphenylarsine; tri-n-butylamine / dimethylformamide / 16 h / 70 °C

2: tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

3: 376 mg / sodium triacetoxyborohydride; AcOH / acetonitrile / 1 h

With tributyl-amine; triphenyl-arsane; tetrabutyl ammonium fluoride; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: Heck reaction;
DOI:10.1021/ja047291m